Lung Cancer Screening Expert Panel : Screening portfolio

In the PLCO control subjects (N = 70,949) the proportion of individuals who met the NLST criteria broken down by their age category at study onset was 16.7% in the 55 to <60 age group, 18.2% in the 60 to <65 age group, 16.6% in the 65 to <70 age group, and 12.9% in the 70 to <75 age group. [...] The age-gender specific rates of meeting the NLST criteria and the lung cancer incidence rates for these groups as observed in the PLCO trial were applied to the Canadian 2010 population age-gender strata to estimate the number of lung cancers observed if LDCT were applied to the Canadian population who met NLST age-eligibility and risk entry criteria. [...] Then sensitivity is represented by the expected incidence in the group screened less the interval cancer rate as a proportion of the expected incidence, that is, the amount of disease destined to occur that did not occur because of the prior screen. [...] These considerations led to the design of the lung cancer screening component of the PLCO trial using CXR.69 Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial The lung cancer component of the PLCO trial differed in several important respects from the earlier trials, specifically with respect to the inclusion of women and never-smokers, the absence of scheduled CXRs in the control group [...] Details of the design and characteristics of the baseline population in the screened arm of the NELSON trial and the DLCST have Lung Cancer Screening.