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Interferon-gamma release assays testing versus tuberculosis skin testing for tuberculosis

24 May 2011

The studies also differed in evaluation of exposure to TB, tests used to identify latent TB, and comorbidities of the study populations.7 The systematic review found that IGRA testing was less likely to have false-positive or false- negative results compared with TST for identifying latent TB in resource-rich, low-TB prevalence IGRA Testing versus Tuberculosis Skin Testing for Tuberculosis. [...] In addition, the results of the HTA were based on studies with small sample sizes (range: 49 to 1,045 indivduals) and that were both clinically and statistically heterogeneous, thus, limiting the accuracy of pooled estimates.7 Systematic reviews and meta-analyses The study characteristics of the systematic reviews and meta-analyses comparing TST testing to IGRA testing are listed in Table 1. The s [...] A summary of the recommendations from each guideline, as well as the critical appraisal of the guidelines, is listed in Table 3. The Appraisal of Guidelines for Research & Evaluation II (AGREE-II) instrument was used to critically appraise the currently available guidelines for identifying TB.20 The majority of guidelines recommend a two-step approach for evaluating a patient for latent TB: start [...] CONCLUSIONS AND IMPLICATIONS FOR DECISION OR POLICY MAKING: The comparative clinical effectiveness of IGRA testing in comparison with TST testing for identification of TB Based on systematic reviews and meta-analyses that compared the effectiveness of IGRA testing to TST testing for identifying TB, IGRA testing does not appear to offer benefit in terms of screening individuals exposed to someone w [...] IGRA testing should be used for diagnosing Domain 4. Clarity of latent TB: Presentation: the as a confirmatory test for a positive TST recommendations within test; the guideline were in combination with a TST for contacts presented clearly and the with a high risk of progression to active format was logical.

health public health research systematic reviews bcg medicine tuberculosis vaccines health care interferon-gamma communicable disease tuberculin test infection clinical medicine tuberculin healthcare policy health treatment health sciences government health care meta-analyses medical specialties virus disease diseases and conditions publication bias interferon mycobacteria tb interferon-gamma release assays quantiferon
Pages
24
Published in
Canada

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