Leukotriene receptor antagonist (LTRA) for asthma : LTRA for asthma

Overall, the review concluded that in asthmatic adults inadequately controlled on low doses of ICS, the addition of LABA is superior to addition of LTRA for preventing exacerbations requiring systematic steroids, and for improving lung function, symptoms, and the use of rescue β2 –agonists. [...] LTRA may be a beneficial long-term treatment for asthma patients15 because of it decreasing the serum lgE levels (note: reduction of free IgE level is a rational target in the treatment of allergic diseases15) Also, it was not inferior to ICS in terms of the percentage of asthma rescue-free days (RFDs)16 or even superior than ICS.17 o In the remaining six RCTs,18-23 LTRA had less favorable outcome [...] ICS+LABA One US RCT,17 published in 2006, reported that the combination of ICS and LABA achieved greater improvements in asthma compared to LTRA monotherapy in terms of the percent of asthma control days. [...] LABA+ICS o In one four-way crossover RCT,24 the combination of LTRA and ICS was showed more effective than the combination of LABA and ICS in terms of reducing sputum eosinophil despite the benefit itself being modest. [...] The reduction of sputum eosinophil count was more in the group with high does of ICS than in one LTRA for Asthma.