In 2014, the United States (US) Centers for Disease Control and Prevention (CDC) released comprehensive clinical practice guidelines for the use of PrEP in the US (8). [...] In 2015, the World Health Organization (WHO) released updated guidance on the use of PrEP for HIV prevention in populations at risk for HIV (9). [...] The Committee for Drug Evaluation and Therapy at the BC Centre for Excellence in HIV/AIDS has been tasked to provide guidance to BC clinicians for the use of TDF/FTC in the context of PrEP. [...] III GUIDANCE ON ThE USE OF hIV PRE-ExPOSURE PROPhyLAxIS (PrEP) 1. Recommendations for PrEP in men who have Sex with men (mSm) and Transgender women (TGw): PrEP is recommended for MSM and TGW at high risk of acquiring HIV infection (GRADE A recommendation for MSM; GRADE B recommendation for TGW). [...] Rationale for use of PrEP in MSM and TGW in BC: 1. MSM constitute the largest at-risk population in BC, making up over 50% of all new HIV diagnoses in the province (11).