Guidance for the Use of Pre - Exposure Prophylaxis (Prep) for the Prevention of Hiv Acquisition in British Columbia

In 2014, the United States (US) Centers for Disease Control and Prevention (CDC) released comprehensive clinical practice guidelines for the use of PrEP in the US (8). [...] In 2015, the World Health Organization (WHO) released updated guidance on the use of PrEP for HIV prevention in populations at risk for HIV (9). [...] The Committee for Drug Evaluation and Therapy at the BC Centre for Excellence in HIV/AIDS has been tasked to provide guidance to BC clinicians for the use of TDF/FTC in the context of PrEP. [...] III GUIDANCE ON THE USE OF HIV PRE-EXPOSURE PROPHYLAXIS (PrEP) 1. Recommendations for PrEP in Men Who Have Sex With Men (MSM) and Transgender Women (TGW): PrEP is recommended for MSM and TGW at high risk of acquiring HIV infection (GRADE A recommendation for MSM; GRADE B recommendation for TGW). [...] Rationale for use of PrEP in MSM and TGW in BC: 1. MSM constitute the largest at-risk population in BC, making up over 50% of all new HIV diagnoses in the province (11).